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KMID : 0377519830080010115
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Chung-Ang Journal of Medicine
1983 Volume.8 No. 1 p.115 ~ p.119
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Rubella Antibody Determination in Primary School Children by ELISA Method
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Lee Hae-Seong
Shim Tae-Sub
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Abstract
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The recognition of the etiologic relationship between rubella and congenital defects of newborns by Gregg, in 1941, established the clinical and public importance of the disease. Thereafter, documentation of the severe teratogenic impact on the disease has stimulated efforts toward control of rubella. Owing to the uncharacteristic symptoms accompanying infections with rubella virus, laboratory diagnostic measures are of decisive importance and there is a great need for a simple assay which can be carried out on large scale for the detection of rubella antibodies. In recent years, the enzyme linked immunosorbent assay(ELISA) technique has come into use in virus serology. This method is a simple rapid and sensitive test for the determination of antibodies against rubella virus. In order to define the distribution of rubella virus antibody in primary school children, Sera samples from 190 healthy boy and girl children(first through sixth grades) attending the primary schools located in Young Deung Po and Dae Rim Dong in July of 1982 were assayed with the enzyme immunosorbent assay method. The results obtained are summarized as follows; 1. Rubella antibody titers(1 : 160 and over) were detected in 103 cases among 190 serum specimens with the positive rate of 54.2%. 2. The prevalence rates of rubella antibody titers were assessed with groups of each grade levels. Statistically, the result did not show any significant differences. 3. The positive rates of antibody distribution by sex and areas did not show any significant differences statistically.
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KEYWORD
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